MicroRNA and self-renewal of cancer stem cells
10.3760/cma.j.issn.1673-422X.2011.11.002
- VernacularTitle:微RNA对肿瘤干细胞自我更新的影响机制
- Author:
Xiaoling MA
;
Hua JIANG
;
Tong CHEN
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Neoplastic stem cells;
Signal transduction
- From:
Journal of International Oncology
2011;38(11):806-809
- CountryChina
- Language:Chinese
-
Abstract:
Cancer stem cells (CSC) are related to the progression,recurrence and drug-resistance of tumor.MicroRNAs have been reported to correlate to the self-renewal of cancer cells.They can regulate cell cycle and thus interfere with the cell fate.Recent publications have clafified that microRNA can effect on cancer stem cells' self-renewal either by regulate targeted genes directly,or through wnt,notch and Hedgehog pathways.
