Expression and clinical significance of EpCAM and β-catenin pathway in colon cancer
10.3760/cma.j.issn.1673-422X.2011.11.022
- VernacularTitle:上皮黏附分子与β-连环蛋白在结肠癌中的表达及临床意义
- Author:
Fengqiang ZHOU
;
Yanmei QI
;
Xinjun LI
;
Huiguang GUO
;
Hong XU
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
Cell adhesion molecules;
Cadherins
- From:
Journal of International Oncology
2011;38(11):873-875
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions and clinical pathological significance of EpCAM and the β-catenin pathway in colon cancer,and the correlation between EpCAM andβ-catenin.Methods Immunohistochemistry was used to detecte the expressions of EpCAM and β-catenin proteins in colon cancer tissues and corresponding adjacent tissues of 70 cases of colon cancer patients,the clinical and pathological features of colon cancer and their relationship were retrospective analyzed.Results ①EpCAM and β-catenin protein expressions in colon cancer tissue was 52 cases (74.3％) and 55 (78.6％) positive respectively; EpCAM and β-catenin proteins in cancer adjacent tissues in 13 cases( 15.7％ ) and 9 cases ( 12.9％ ) were positive,the differences were statistically significant.②the EpCAM expression is positively correlated with the β-catenin expression ( r =0.616,P ＜ 0.01 ).③The expressions of EpCAM and β-catenin correlated with the tumor differentiation,invasion depth,lymph node metastasis and TNM staging related ( P ＜ 0.05).Conclusion EpCAM and β-catenin pathways in colon cancer positively correlate,and closely correlate with colon cancer.The expression level of EpCAM and β-catenin can be used as a reference for the colon disease course and healing.
