Relationship between giomerulus podocyte injury and hyperlipidemia in IgA nephropathy
10.3760/cma.j.issn.1673-4904.2011.28.009
- VernacularTitle:IgA肾病肾小球足细胞损伤与高脂血症的关系
- Author:
Liping ZHANG
;
Zhe YAN
;
Lin YANG
;
Shuxia FU
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis,IGA;
Podocytes;
Hyperlipidemias
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(28):26-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of hyperlipidemia on glomerulus podocyte injury with IgA nephropathy.Methods Fifty-one IgA nephropathy patients with biopsy-proven were selected.Immunohistochemistry was applied to detect the expression of WT1,a marker of podocyte,in the renal tissue of patients with IgA nephropathy.The density of podocyte per glomerulus wascalculated using specific software.Results Triglyceride (TG) was positively correlated with glomerulus podocyte injury,serumcreatinine and glomerulosclerosis in IgA nephropathy (r =0.549,0.770,0.698,P ＜ 0.05 or ＜ 0.01 ),and there was no correlation with 24 h proteinuria.The expression of WT1 was significantly decreased in glomerulus of patients with IgA nephropathy (P ＜ 0.01 ).There was no correlation between the expression of WT1 and 24 h proteinuria,but the expression of WT1 was positively correlated with serum creatinine and glomerulosclerosis (r =0.765,0.679,P ＜0.01).Conclusion Hyperlipidemia may induce glomerulus podocyte injury in IgA nephropathy,and it may contribute to the progression of IgA nephropathy.
