Gene modified dendritic cell vaccine in anti-tumor immunity
10.3760/cma.j.issn.1673-4203.2011.11.015
- VernacularTitle:基因修饰的树突状细胞疫苗诱导抗肿瘤免疫
- Author:
Tuo YI
;
Weixin NIU
- Publication Type:Journal Article
- Keywords:
Dendritic cells;
Gene therapy;
Immunotherapy
- From:
International Journal of Surgery
2011;38(11):767-770
- CountryChina
- Language:Chinese
-
Abstract:
Dendritic cells(DCs) are the most potent antigen presenting cells,which play a vital role in the initiation of immune response by presenting antigens to T cells and followed by induction of T-cell response.This established function of dendritic cells has attracted much attention in efforts to develop useful vaccines for the treatment of cancer.In several studies,DCs were genetically engineered by tumor-associated antigens or by immune molecules such as costimulatory molecules,cytokines,and chemokines.These new DC vaccines are more powerful in stimulating anti-tumor immunity.This review focuses on DC gene modifications for enhancing the multiple effector functions of DC,a variety of transferred genes,and recent clinical trials.
