Research progress on Caveolin-1 in pancreatic cancer
10.3760/cma.j.issn.1673-4203.2011.11.016
- VernacularTitle:窖蛋白-1与胰腺癌关系的研究进展
- Author:
Xiaohui WANG
;
Fei LI
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Caveolin- 1;
Cell- signaling;
Invasion;
Metastasis
- From:
International Journal of Surgery
2011;38(11):770-774
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is the fourth most common cause of cancer death,with a 5- year survival rate of less than 5％.The management and prognosis of the patients have remained dismal due to higher resistance of cancer cells to conventional approaches including surgery,radiation and chemotherapy.Therefore,there is a need for development of specific and sensitive tumor marker for pancreatic cancer.Caveolin- 1 is an essential constituent of caveolae and interacts with a variety of cellular proteins and regulates cell- signaling events.In this review,we survey the functional roles of caveolin- 1 in pancreatic cancer and argue that caveolin-1 regulates multiple cancer-associated processes including tumor growth,cell invasion,metastasis,cell apeptosis.However,Caveolin-1 has been reported to impact both positively and negatively on various aspects of pancreatic cancer progression.The function of caveolin- 1 is interdependent on tumor stage and the expression of some signaling pathways that impact on its role during tumor progression.
