Epithelial-mesenchymal transition and cancer stem cells

VernacularTitle:上皮间质转化与肿瘤干细胞
Author: Yan GAO ; Xiumei MA
Publication Type:Journal Article
Keywords: Neoplastic stem cells; Therapy; Epithelial-mesenchymal transitions
From: Journal of International Oncology 2011;38(11):809-813
CountryChina
Language:Chinese
Abstract: Epithelial-mesenchymal transition (EMT) is the basis of biological process of embryonic development,and is also closely related with tumor cell in situ invasion and distant metastasis.Recent studies find that EMT and cancer stem cells (CSCs) have a close relationship.CSCs have a strong ability to selfrenewal,tumorigenicity and cell differentiation potential.Identifing the markers,in-depth study of CSCs resistance,may provide a new path for cancer treatment.