Myeloid derived suppressor cells mediated suppress immunity
10.3760/cma.j.issn.1673-422X.2011.11.004
- VernacularTitle:髓源性抑制细胞介导的免疫抑制
- Author:
Baohong YANG
;
Jinpu YU
;
Xiubao REN
- Publication Type:Journal Article
- Keywords:
Immunosuppression;
Neoplasms;
Amino acids;
Myeloid derived suppressor cells
- From:
Journal of International Oncology
2011;38(11):813-816
- CountryChina
- Language:Chinese
-
Abstract:
There exists a population of myeloid-origin cells that are associated with tumor immune escape in cancer patients,commonly termed as myeloid derived suppressor cells(MDSCs).M DSCs accumulate in the blood,lymph nodes,bone marrow,and inhibit both adptive and innate immunity.Different suppressive mechanisms are used by MDSCs to block tumor immunity.Reducing the numbers of MDSCs or inhibiting the suppressive pathway conducted by MDSCs will bring new highlight to biotherapy in tumor treatment.
