Effects of insulinoma-glucagonoma clone 20 isoforms on cancer cells
10.3760/cma.j.issn.1673-422X.2011.11.005
- VernacularTitle:胰岛素-胰高血糖素瘤克隆20在肿瘤细胞中的作用
- Author:
Yuping WEI
;
Liang DONG
;
Wenxiang BI
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Apoptosis;
Caspases;
Tumor necrosis factor-alpha
- From:
Journal of International Oncology
2011;38(11):816-819
- CountryChina
- Language:Chinese
-
Abstract:
Insulinoma-glucagonoma clone 20 can express at least 6 isoforms in human cells.These isoforms can affect cell apoptosis and proliferation through apoptosis related signaling pathway,such as TRAIL or TNF signaling pathways.Furthermore,insulinoma-glucagonoma clone 20,as a GTP-GDP exchange factor,participates in the transportation of nerve synaptophysins.
