Mutual regulation between miRNA and DNA methylation in gastric cancer
10.3760/cma.j.issn.1673-422X.2011.09.013
- VernacularTitle:微小RNA与DNA甲基化相互调控在胃癌中的作用
- Author:
Yang LI
;
Wentian LIU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
MicroRNAs;
DNA methylation
- From:
Journal of International Oncology
2011;38(9):684-687
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetic modification plays an important role in the development and prognosis of gastric cancer.MicroRNA (miRNA) and DNA methylation are two important epigenetic control mechanisms.MiRNA inhibits the translation of target messenger RNA (mRNA),and is involved in post-transcriptional regulation.Abnormal methylation of promoter CpG island is closely related with the tumorigenesis,which can lead to abnormal expression of cancer gene,tumor-suppressor gene or other tumor-related gene.The mutual regulation between miRNA and DNA methylation plays an important role in gastric cancer,and the regulation network provides a new direction for the diagnosis and treatment of gastric cancer.
