Activating transcription factor 4 in malignant tumors and drug resistance
10.3760/cma.j.issn.1673-422X.2011.10.005
- VernacularTitle:活化转录因子4与肿瘤的发生发展及耐药
- Author:
Zhuhong ZHANG
;
Zhiyan FU
;
Chenghu LIU
- Publication Type:Journal Article
- Keywords:
Transcription factor;
Neoplasms;
Growth;
Drug therapy
- From:
Journal of International Oncology
2011;38(10):735-737
- CountryChina
- Language:Chinese
-
Abstract:
Activating transcription factor 4 ( ATF4),one of the activating transcription factors,belongs to the cyclic AMP response element binding protein family.The expression of ATF4 is up-regulated by tumor micro-environmental factors.And ATF4 regulates the processes of tumor growth,infiltration,metastasis,apoptosis and drug resistance.Therefore,ATF4 might serve as a potential therapeutic target in cancer.
