Lung cancer stem cells
10.3760/cma.j.issn.1673-422X.2011.10.014
- VernacularTitle:肺癌干细胞
- Author:
Mei JIANG
;
Wentao YUE
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Neoplastic stem cells
- From:
Journal of International Oncology
2011;38(10):761-764
- CountryChina
- Language:Chinese
-
Abstract:
Recently,studies have demonstrated that several signaling pathways including Wnt,Notch,and Hedgehog which are involved in the regulation of the stem cells are abnormally activated in lung cancer.They are closely associated with some properties of the lung cancer stem cells,such as high tumorigenic,high metastasis,drug resistance and so on.In addition,several studies have shown that the population of the lung cancer stem cells,which are resistant to radiotherapy and chemotherapy significantly,highly express drug resistance proteins.Therefore,how to target lung cancer stem cells and ultimately cure the disease is becoming a hotspot in the cancer targeted therapy.
