Family of ADAMs and gastric and colorectal cancer
10.3760/cma.j.issn.1673-422X.2011.11.016
- VernacularTitle:去整合素金属蛋白酶家族及其与胃肠道肿瘤的关系
- Author:
Weiqiang ZHENG
;
Kaixiong TAO
- Publication Type:Journal Article
- Keywords:
ADAM proteins;
Gastrointestinal neoplasms
- From:
Journal of International Oncology
2011;38(11):852-854
- CountryChina
- Language:Chinese
-
Abstract:
The ADAMs(a disintegrin and metalloproteinase) are a family of transmembrane or secreted proteins with important roles in cell fusion,adhesion,degradation of extracellular matrix,proteolysis,and signaling.The most important domains of ADAMs includes metalloprotease domain and disintegrin domain.Some ADAMs have been observed in gastric and colorectai cancer,and produced a marked effects during the tumor development and metastasis.The further research of ADAMs may provide more choices for tumor target therapy.
