Relationship of Foxp3 and lung cancer
10.3760/cma.j.issn.1673-422X.2011.09.011
- VernacularTitle:转录因子Foxp3与肺癌
- Author:
Jing GUO
;
Juyong WANG
;
Zhan ZHENG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Foxp3;
Regulatory T cells
- From:
Journal of International Oncology
2011;38(9):677-679
- CountryChina
- Language:Chinese
-
Abstract:
Foxp3 is a novel member of forkhead and winged-helix transcription factor family.Foxp3 is specifically expressed in CD4+ CD25 + regulatory T cells,and Foxp3 is a critical regulator of CD4+ CD25 + regulatory T cell development and function maintain.With the development of molecular biology techniques,the understanding of Foxp3's structure and function is increasingly clear.Foxp3 plays an important role in the lung cancer's development,clinical treatment and prognosis.Thus to clarify the regulatory mechanism of Foxp3 expression is beneficial for the explanation of lung cancer's immunal environment and the establishment of a better immunal therapeutic regimen,so as to provide profound significance for lung cancer's prevention and treatment.
