Adiponectin as a new paradigm for approaching Alzheimer's disease.
10.5115/acb.2013.46.4.229
- Author:
Juhyun SONG
1
;
Jong Eun LEE
Author Information
1. Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea. jelee@yuhs.ac
- Publication Type:Review
- Keywords:
Adiponectin;
Alzheimer's disease;
Brain insulin system;
Cognitive impairment
- MeSH:
Adiponectin*;
Adipose Tissue;
Alzheimer Disease*;
Cardiovascular Diseases;
Glucose;
Homeostasis;
Immune System;
Insulin;
Memory;
Metabolism;
Neurodegenerative Diseases;
Obesity
- From:Anatomy & Cell Biology
2013;46(4):229-234
- CountryRepublic of Korea
- Language:English
-
Abstract:
Adiponectin is an adipocytokine released by the adipose tissue and has multiple roles in the immune system and in the metabolic syndromes such as cardiovascular disease, Type 2 diabetes, obesity and also in the neurodegenerative disorders including Alzheimer's disease. Adiponectin regulates the sensitivity of insulin, fatty acid catabolism, glucose homeostasis and anti-inflammatory system through various mechanisms. Previous studies demonstrated that adiponectin modulates memory and cognitive impairment and contributes to the deregulated glucose metabolism and mitochondrial dysfunction observed in Alzheimer's disease. Here, we aim to summarize recent studies that suggest the potential correlation between adiponectin and Alzheimer's disease.
