Effect and mechanism of mesenchymal stem cells on cancer cells
10.3760/cma.j.issn.1673-422X.2011.10.002
- VernacularTitle:间充质干细胞对肿瘤细胞的分子作用机制
- Author:
Jingyan JIANG
;
Dong LI
;
Yuxia WANG
;
Fenglan LI
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cells;
Neoplasms;
Molecular mechanisms of action
- From:
Journal of International Oncology
2011;38(10):725-728
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells (MSCs) not only exhibit a marked tropism for tumors,but also exert antitumorigenic activity or as an emerging vectors to express foreign genes continuously and efficiently within the tumor microenvironment,suppress tumor's growth and metastasis.Conversely,MSCs can accelerate tumor development through promoting tumor stroma remodeling and tumor vascular formation,inhibiting tumor local immune and changing tumor phenotype.The reason for this discrepancy may be attributable to different sources of MSCs,the heterogeneity of MSCs,differences in tumor microenviroment,or another factor that is not yet appreciated.
