Let-7 and HMGA in tumors
10.3760/cma.j.issn.1673-422X.2011.09.002
- VernacularTitle:let-7与高迁移率族蛋白A在肿瘤中的研究进展
- Author:
Jie BAI
;
Kaixiong TAO
- Publication Type:Journal Article
- Keywords:
Neoplasms;
High mobility group proteins;
Let-7
- From:
Journal of International Oncology
2011;38(9):646-649
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group protein A (HMGA) plays a critical role in the development of a variety of tumors.It's expression level will abnormally increase with the increase of the malignant degrees of astrocytoma and metastasis potential.Let-7 which is a kind of small RNA endogenous coding negatively regulates HMGA genes as a tumor suppressor.The expression of let-7 reduces while HMGA rises in many kinds of tumors was obversed.Therefore,this finding provides new references for the early diagnosis of tumor and also provides new approaches for therapy of tumor.
