Role of microRNA in hepatocellular carcinoma and liver cancer stem cells

VernacularTitle:微小RNA在肝细胞癌及肝癌干细胞中的作用
Author: Zhe GUO ; Bangde XIANG
Publication Type:Journal Article
Keywords: MicroRNAs; Carcinoma,hepatocellular; Neoplastic stem cells
From: Journal of International Oncology 2011;38(9):680-683
CountryChina
Language:Chinese
Abstract: MicroRNA (miRNA) is a class of small ( about 22 nueleotides),single-stranded and noncoding RNA molecule.It is demonstrated that miRNAs participate in a wide array of physiologic processes,such as the development of early embryos and organ,cell proliferation,differentiation and apoptosis.MiRNAwhich has abnormal expression in hepatocellular carcinoma is closely related to the occurrence,developmentand metastasis of liver cancer.Liver cancer stem cells may be the root of cancer recurrence and metastasis.Researches have provided clear evidence that some kinds of miRNAs are important regulators in serf-renewal and differentiation of cancer stem cells.Therefore,regulating the expression of miRNAs in hepatoma cells and liver cancer stem cells may be a new approach to treat hepatocellular carcinoma or prevent the recurrence after treatment.