Expression and significance of histone deacetylase 6 in non-small cell lung cancer
10.3760/cma.j.issn.1673-422X.2011.09.022
- VernacularTitle:组蛋白去乙酰化酶6在非小细胞肺癌组织中的表达及意义
- Author:
Chunhua XU
;
Like YU
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Immunohistochemistry;
Histone deacetylase 6
- From:
Journal of International Oncology
2011;38(9):715-717
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of histone deacetylase 6 (HDAC6) and its significance in non-small cell lung cancer (NSCLC).Methods The expression of HDAC6 was measured by SP staining in 70 cases of NSCLC and 18 cases of normal lung tissues.Results Positive rate of HDAC6 immunostaining in NSCLC was 58.57％,which was significantly higher than 16.67％ in normal lung tissues(P ＜0.01 ).No correlation was found between HDAC6 expression and the age,sex,differentiated level,histological type ( P ＞0.05).But the expression level of HDAC6 was closely related to clinical stage and lymph node metastasis in NSCLC patients ( P ＜ 0.05 ).Conclusion HDAC6 over expression may be related to the pathogenesis and development of NSCLC.
