The clinical value of activated protein C in pediatric leukemia patients with acute lung injury
10.3760/cma.j.issn.1673-4912.2011.05.007
- VernacularTitle:白血病患儿并发急性肺损伤时血浆活化蛋白C的变化及意义
- Author:
Kang AN
;
Ying WANG
;
Biru LI
;
Juan QIAN
;
Yanwen YANG
- Publication Type:Journal Article
- Keywords:
Acute lung injury;
Activated protein C;
Leukemia;
Childrer
- From:
Chinese Pediatric Emergency Medicine
2011;18(5):403-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of plasma activated protein C(APC)in the pediatric leukemia patients with acute lung injury(ALI),and the relationship with the outcome.Methods During the study period(from Jan to Dec 2009),17 pediatric leukemia patients with ALI were selected.They were divided into neutropenic(n =10)and non-neutropenic(n =7)group.We collected the basic data including the age,gender,stage of chemotherapy,pediatric critical illness score,mechanical ventilation time,ICU time.The blood gas and plasma APC levels were detected on day 1 and day 4 of ALI onset.Results Compared with the non-neutropenic group,the neutropenic group had a significantly longer mechanical ventilation time [(16.60 ± 1 0.83)d vs(3.79 ± 4.08)d,P =0.009 6],lower PaO2 level on day l[(54.90 ± 17.05)mm Hg vs (92.70 ± 27.53)mm Hg,P =0.009 7],and lower APC level on day 4[(193.06 ± 63.19)pg/mlvs(286.28 ±25.12)pg/ml,P =0.007 7].Conclusion The APC generation is severely impaired in the neutropenic group,especially in those who died.The lower APC level is,the longer is the mechanical ventilation time,the worse is oxygenation,the poorer is the prognosis.APC replacement therapy may be promising in these patients.
