Risk factors of bronchopulmonary dysplasia in very low birth weight infants

VernacularTitle:极低出生体质量儿支气管肺发育不良的临床高危因素分析
Author: Yanmin BAO ; Xiaohong LIU ; Yimin ZHENG ; Hui YANG ; Teng LI ; Jinxing FENG
Publication Type:Journal Article
Keywords: Very low birth weight infant; Bronchopulmonary dysplasia; Risk factors; Infant,newborn
From: Chinese Pediatric Emergency Medicine 2011;18(5):410-412
CountryChina
Language:Chinese
Abstract: Objective To investigate the risk factors of bronchopulmonary dysplasia(BPD)in very low birth weight infant.Methods The clinical data of 49 very low birth weight infants in our NICU from Sep 2006 to Sep 2009 were reviewed,and divided into BPD group(n =15)and without BPD group(n =34).The risk factors of BPD were analysed.Results Compared with the infants without BPD,there were significant differences in gestational age[(29.30 ± 1.48)week vs(30.54 ± 1.60)week],hospital-acquired infection(9 cases vs 10 cases),intrauterine infection(9 cases vs 8 cases),the time for continuous positive airway pressure(CPAP)[(12.47 ± 5.83)d vs(4.24 ± 4.19)d],the time for hyperoxia[(1.47 ± 1.41)d vs (0.18 ±0.63)d],patent ductus arteriosus(5 cases vs 1 cases)(P＜0.05).Logistic regression revealed that intrauterine infection and the time for CPAP were independent risk factors of BPD(P ＜0.05).Conclusion Prophylaxis of intrauterine infection may decrease the mortality and severity of BPD.The prolonged time for CPAP may predict the risk of BPD.