Prognostic factors of the invasion and metastasis of gastric cancer and their applications in targeted therapy
10.3760/cma.j.issn.1673-4203.2011.10.019
- VernacularTitle:胃癌侵袭转移的影响因素分析及靶向治疗进展
- Author:
Qing LIU
;
Changle ZHANG
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
Invasion and metastasis;
Prognostic factor;
Targeted therapies
- From:
International Journal of Surgery
2011;38(10):707-710
- CountryChina
- Language:Chinese
-
Abstract:
Invasion and metastasis are critical determinants on cancer morbidity.Genes and molecules participating in these steps have been demonstrated as potential prognostic factors.Growth factors and their receptors,cell-cycle regulators,cell-adhesion molecules and m trix-degrading enzymes are potentially used as prognostic factors.However,increased understandings for molecular mechanisms underlying carcinogenesis and its implementation in the treatment of gastric cancers have recently been focused on the development and incorporation of targeted agents with chemotherapy.
