Cell-based delivery of oncolytic viruses
10.3760/cma.j.issn.1673-422X.2011.10.001
- VernacularTitle:细胞荷载溶瘤病毒
- Author:
Zunyou XU
;
Lijun MAO
;
Jiacun CHEN
- Publication Type:Journal Article
- Keywords:
Oncolytic viruses;
Neoplasms;
Therapy
- From:
Journal of International Oncology
2011;38(10):723-725
- CountryChina
- Language:Chinese
-
Abstract:
Oncolytic viruses,a novel class of virus vectors,which selectively replicate only in tumor cells,have excellent tumor targeting and good tansfection efficiency.Many oncolytic viruses have apparent curative effect when administered intratumorally.However,the host immune system remains a critical obstacle to systemic administration of virotherapeutics.It appears that cell-based delivery of oncolytic viruses could offer one solution to this critical problem,which provides a new platform to the biological therapy of cancer.
