Function of suppressors of cytokine signaling 1 in dendritic cells-based tumor vaccines
10.3760/cma.j.issn.1673-422X.2011.10.003
- VernacularTitle:细胞因子信号抑制因子1在树突状细胞肿瘤疫苗中的作用
- Author:
Yingyi XU
;
Yuqiang CHEN
- Publication Type:Journal Article
- Keywords:
Dendritic cells;
Cancer vaccines;
SOCS1
- From:
Journal of International Oncology
2011;38(10):729-732
- CountryChina
- Language:Chinese
-
Abstract:
Dendritic cells (DCs) are the important auxiliary cells in tumor vaccines to activate antitumor immunity.Suppressor of cytokine signaling 1 ( SOCS1 ) has been shown to play an important role in inhibition of cytokine signal transduction.Recent studies show that inhibition of the function of SOCS1 in DCs plays a critical role in strongly enhancing tumor vaccines antitumor activity,and in the methods of restraining SOCS1 's function have also made significant progress.
