Tumor-related microRNA targeting PTEN
10.3760/cma.j.issn.1673-422X.2011.10.004
- VernacularTitle:靶向PTEN的肿瘤相关微小RNA
- Author:
Yang SHUO
;
Gao AI
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
PTEN phosphohydrolase;
Neoplasms
- From:
Journal of International Oncology
2011;38(10):732-735
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs are the endogenous non-coding RNAs that regulate gene expression by mediating gene post-transcriptional silence.Among them,miR-21,miR-17-92,miR-214,miR-26a,miR-221,miR-222and so on mainly suppress the expression of PTEN phosphohydrolase through targeting PTEN mRNA 3'-UTR.PTEN plays an important role in cell proliferation,apoptosis,migration and invasion,and its low expression will induce tumorigenesis.
