Clinical research on the D-dimer changes in haemolytic disease of newborn
10.3760/cma.j.issn.1673-4904.2011.27.012
- VernacularTitle:新生儿溶血病D-二聚体变化的临床研究
- Author:
Haiyan CAI
;
Yuyan YANG
;
Caiyun GAO
;
Aixia YAN
;
Shuzhong WANG
;
Min WANG
- Publication Type:Journal Article
- Keywords:
Infant,newborn;
Erythroblastosis,fetal;
D-dimer
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(27):31-33
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the change of D-dimer in haemolytic disease of newborn and its clinical significance. MethodsSixty cases with haemolytic disease of newborn were divided into nonserious group(34 cases) and serious group(26 cases) by the level of bilirubin, 40 cases of normal neonatus (control group) were also selected. The levels of D-dimer and fibrinogen(FIB) were measured and compared.ResultsThe level of D-dimer in serious group and non-serious group[ (9.29 ± 11.34), (0.84 ± 0.77 ) mg/L]was higher than that in control group [ (0.45 ± 0.06) mg/L](P ＜ 0.01 or ＜ 0.05 ),the level of D-dimer in serious group was higher than that in non-serious group (P＜ 0.01 ). There was no significant difference in the level of FIB among the three groups (P ＞ 0.05). ConclusionsThere is hypercoagulability in the serious haemolytic disease of newborn. It is valuable to detect plasma D-dimer density for serious haemolytic disease of judgement and treatment.
