Effect of ginkgo biloba extract capsules on level of plasma brain natriuretic peptide and cardiovascular event in diabetic nephropathy patients
10.3760/cma.j.issn.1673-4904.2011.25.003
- VernacularTitle:银杏叶胶囊降低糖尿病肾病患者血浆脑钠肽水平并降低心血管事件的发生概率
- Author:
Huihui LIU
;
Dianjun LIU
;
Shaojiang TIAN
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,brain;
Diabetic nephropathies;
Cardiovascular event;
Ginkgo biloba extract capsules
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(25):7-10
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the predictor and prophylaxis of cardiovascular events in diabetic nephropathy (DN) patients. MethodsFifty-eight cases of DN patients were assigned randomizedly to two groups. Conventional treatment group(33 cases) received conventional treatment, and ginkgo biloba extract group(30 cases) received extra ginkgo biloba extract capsules treatment. Plasma examination for blood fat, blood pressure(Bp), brain natriuretic peptide(BNP) and echocardiogram was performed every 3 months. All the patients were followed-up for the occurrence of cardiovascular events. ResultsThere were no significant differences in age, sex, Bp, blood fat, serum creatinine, hemoglobin,BNP, left ventricular E/A and left ventricular ejection fraction (LVEF) in two groups at the time of recruitment. After treatment of 12 months, the level of plasma BNP decreased significantly in ginkgo biloba extract group and maintained in the lower levels throughout the follow-up compared with that in conventional treatment group(P＜ 0.01 ). After treatment of 18 and 24 months, left ventricular E/A and LVEF were better in ginkgo biloba extract group than those in conventional treatment group(P ＜ 0.01 or ＜ 0.05 ). In ginkgo biloba extract group, the level of plasma BNP after treatment of 12 months had correlation with left ventricular E/A and LVEF after treatment of 24 months (r =0.61, -0.68, P ＜ 0.05 ). Survival analysis indicated that the level of plasma BNP was a predictor of cardiovascular event in DN patients. ConclusionThe level of plasma BNP can be used as a predictor of cardiovascular event in DN patients,and ginkgo biloba extract capsules can decrease the level of plasma BNP and reduce the incidence of cardiovascular events in DN patients.
