Value of early secretory antigenic target 6 in the early diagnosis of tuberculous meningitis
10.3760/cma.j.issn.1673-4904.2011.25.005
- VernacularTitle:早期分泌靶抗原6在结核性脑膜炎早期诊断中的价值
- Author:
Wei GE
;
Na LI
;
Xia SHEN
;
Deqin GENG
- Publication Type:Journal Article
- Keywords:
Tuberculosis,meningeal;
Early diagnosis;
Monocytes;
Early secretory antigenic target 6;
Cerebrospinal fluid
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(25):14-17
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the value of early secretory antigenic target 6 (ESAT-6) in monocytes of cerebrospinal fluid (CSF) in the early diagnosis and judgment of the tuberculous meningitis (TBM). MethodsForty cases with TBM (TBM group) and 40 patients with other meningitis patients (control group,9 cases with purulent meningitis,24 cases with viral meningitis,3 cases with cryptococcal meningitis,3 cases with cerebral cysticercosis, 1 case with neurosyphyilis) were involved in this study.Conventional examination of CSF was inspected after admission, and the ESAT-6 in monocytes of CSF was detected by immunocytochemical stain. ResultsThe positive rate of ESAT-6 was 24％ in TBM group and 0 in control group (P ＜ 0.01 ). In ROC curve, if the rate of ESAT-6 ≥8.5％ judged as positive, and ＜ 8.5％ judged as negative, 35 patients of TBM group and 4 patients of control group were ESAT-6 positive. The sensitivity of the ESAT-6 in the diagnosis of TBM was 87.5％, and the specificity of TBM was 90.0％. Thirty patients in TBM group were not given anti-tuberculosis drug treatment, and the positive rate of ESAT-6 was 93.3％ (28/30) before treatment, and was 46.7％ (14/30) after treatment of 2 weeks (P =0.000).ConclusionsESAT-6 in monocytes of CSF detected by immunocytochemical stain has higher sensitivity and specificity in the diagnosis of TBM in early stage. Observing the positive rate of ESAT-6 dynamicly has practical value in judgment the severity of TBM.
