Expression of Ezrin and inducible nitric oxide synthase and their correlation in colonic adenoma

VernacularTitle:结肠腺瘤组织Ezrin蛋白和诱导型一氧化氮合酶表达及其生物学意义的探讨
Author: Weilin LONG ; Duju QING ; Zhijun GONG
Publication Type:Journal Article
Keywords: Adenomatous polyposis coli; Nitric oxide synthase; Ezrin; Ki-67 nuclear antigen
From: Chinese Journal of Postgraduates of Medicine 2011;34(26):16-19
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the expression of Ezrin and inducible nitric oxide synthase (iNOS) and their correlation to malignant proliferation of colonic adenoma. MethodExpressions of Ezrin,iNOS and nuclear Ki-67 antigen were detected by immunohistochemistry in tubular adenoma (60 cases),villous adenoma(40 cases) and malignant (30 cases ) pleomorphic adenoma. ResultsExpressions of Ezrin,iNOS in tubular adenoma [58.3％ (35/60), 50.0％ (30/60)], villous adenoma [72.5％ (29/40), 70.00(28/40)]and malignant pleomorphic adenoma [96.7％(29/30),93.3％(28/30)]were gradually increased ( X2 = 11.600,P = 0.005; X2 = 8.451, P = 0.015 ). There was a significant positive correlation between the expression of Ezrin and iNOS (r = 0.765, P ＜ 0.01 ). Nuclear Ki-67 antigen proliferation index was increased with the increasing of Ezrin and iNOS expressions. ConclusionOverexpression of Ezrin and iNOS may promote proliferation and malignant transformation of colonic adenoma.