Significance of ARHI protein in adenocarcinoma of the uterine cervix

VernacularTitle:ARHI蛋白在宫颈腺癌病因学中的意义研究
Author: Kuiran LIU ; Min ZHAO
Publication Type:Journal Article
Keywords: Uterine cervical neoplasms; Immunohistochemistry; ARHI protein
From: Chinese Journal of Postgraduates of Medicine 2011;34(24):1-3
CountryChina
Language:Chinese
Abstract: ObjectiveTo detect the expression of ARHI protein in adenocarcinoma of the uterine cervix and normal uterine cervix tissue, and explore the pathogenesis of cervical cancer. MethodsThe expression of ARHI protein in 30 cases of adenocarcinoma of the uterine cervix tissue and 30 cases of normal uterine cervix tissue was detected by immunohistochemistry and analyzed the relationship between ARHI protein and adenocarcinoma of the uterine cervix. ResultsThe expression of ARHI protein in adenocarcinoma of the uterine cervix tissue[46.67％(14/30)]was lower than that in normal uterine cervix tissue[90.00％(27/30)],the difference was significant (P＜0.05). There was intimate correlation between ARHI protein and histological grade, FIGO stage of adenocarcinoma of the uterine cervix tissue (P ＜ 0.05), there was no correlation between ARHI protein and lymphatic metastasis (P＞0.05). ConclusionsThe expression of ARHI protein in adenooarcinoma of the uterine cervix decreases which indicates the expression of ARHI protein take part in the carcinogenesis of adenocarcinoma of the uterine cervix. It can be used as a new diagnostic indicator of adenocarcinoma of the uterine cervix.