Context.sensitive half-times of etomidate
10.3760/cma.j.issn.1673-4904.2011.27.001
- VernacularTitle:依托咪酯的即时输注半衰期
- Author:
Youchun LI
;
Zhiping WANG
- Publication Type:Journal Article
- Keywords:
Etomidate;
Half-life;
Chromatography,high pressure liquid
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(27):1-3
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the context-sensitive half-times of etomidate. Methods Twenty patients ( ASA Ⅰ - Ⅱ ) underwent selective thoracic operation were divided into 2 groups by random digits table with 10 cases each,the patients were allocated to receive either continuous infusion etomidate 10μg/(kg·min) for 1 h(Gl group) or continuous infusion etomidate 10 μg/(kg·min) for 2 h(G2 group) of maintenance anesthesia. The samples were collected at the following time points: 1 min before stop infusion,2,5, 10,15,20,30,40,50 and 60 min after stop infusion. The plasma concentrations of etomidate were measured by high-performance liquid chromatography and the changes of the context-sensitive half-times of etomidate were calculated. ResultsThe context-sensitive half-times of etomidate was ( 17.1 ± 13.1 )min in G1 group and (21.7 ± 15.1 ) min in G2 group. There was no significant difference between two groups (P＞0.05). ConclusionThe context-sensitive half-times of etomidate is short and its pharmacokinetic profile is suitable for continuous infusion.
