The effect of tramadol on perioperative insulin resistance in patients undergoing pulmonary lobectomy
10.3760/cma.j.issn.1008-6706.2011.20.009
- VernacularTitle:曲马朵对肺叶切除术患者围手术期胰岛素抵抗的影响
- Author:
Rui MA
;
Zhiqiang LI
;
Junmei XU
;
Zhenxing XU
- Publication Type:Journal Article
- Keywords:
Tramadol;
Intraoperative period;
Insulin resistance;
Tumor necrosis factor;
Interleukin-6
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(20):2753-2755
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of tramadol on perioperative insulin resistance in patients un dergoing pulmonary lobectomy.MethodsThirty patients undergoing pulmonary lobectomy,were randomly divided in to two groups :group T(tramadol group)and group C (control group), five minutes before skin incison, group T re ceived tramadol 1.5 mg/kg intravenously (IV), followed immediately by a continuous infusin of 0.5mg/kg per hour until the end of surgery, and the control group received normal saline instead of tramadol.Blood samples were takenfrom vein for determination of plasma blood sugar,insulin, IL-6 and TNF-α concentrations before induction of anesthe sia(T0) ,at the end of the operation(T1) ,four hours after operation(T2)and seven oclock on the next morning(T3),and the value of ISI was calculated.ResultsThe concentrations of blood sugar, insulin,TNF-α and IL-6 at T1 andT2 ,T3 increased significantly compared to baseline(T0) in both groups(P ＜ 0.05).The concentrations of blood sugar,insulin,IL-6 and TNF-o at T1 ,T2 and T3 were significantly lower in group T than that in group C (P ＜0.05).Thevalue of ISI was significantly higher in group T than that in group C (P ＜ 0.05).ConclusionTramadol could allevi ate perioperative insulin resistance in patients undergoing pulmonary lobectomy by inhibiting plasma blood sugar,insu lin,IL-6 and TNF-α.
