Clinical research of early high-loading-dose dopidogrel in treatment of patients with acute coronary syndrome
10.3760/cma.j.issn.1008-6706.2011.20.006
- VernacularTitle:早期高负荷剂量氯吡格雷治疗急性冠脉综合征
- Author:
Jinliang LI
;
Zhaoying YANG
;
Weimin WANG
;
Jian KONG
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
High-loading-dose;
Clopidogrel
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(20):2747-2748
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effects and safety of early high-loading-dose clopidogrel in treatment of patients with acute coronary syndrome.Methods178 patients with STEMI were divided into two groups randomly.96patients were treated with clopidogrel 600 mg immediately when they came to the hospital, and then were treated with clopidogrel 75mg daily for 1 year;82 patients were treated with clopidogrel 300mg immediately when they came to the hospital,and then were treated with clopidogrel 75mg daily for 1 year.The attacks of postinfarction angina pectoris,events of heart failure and the composite of death,reinfarction or stroke were observed.ResultsCompared with control group, the high-loading-dose group had obvious reduction in the attacks of postinfarction angina pectoris and the composite of death, reinfarction or stroke (all p ＜ O.05).There were no major and minor bleeding events in the two groups.ConclusionEarly treatment with high-loading-dose of clopidogrel in ACS could significantly improve its prognosis,and was safe and well tolerated.
