Observation on the effect of vinpocetine sustained-release capsules on post-stroke depression and recovery of neurological function
10.3760/cma.j.issn.1008-6706.2011.18.012
- VernacularTitle:长春胺缓释胶囊对卒中后抑郁和神经功能恢复的作用观察
- Author:
Lianghong KUANG
;
Sheng XIAO
;
Jinsong XIAO
- Publication Type:Journal Article
- Keywords:
Cerebrovascular accident;
Vinpocetine;
Depression;
Neurological function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(18):2471-2473
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effect of vinpocetine sustained-release capsules on post-stroke depression and recovery of neurological function. MethodsA total of 64 patients with acute post-stroke depression were randomly divided into Vinpocetine sustained-release capsules group( 34 cases) and control group(30 cases). Conventional therapy was given to both groups. To the treatment group, vinpocetine sustained-release capsules was given at the same time. Depression status was assessed with Hamilton Rating Depression Scale(HAMD). Meanwhile ,Mimi-Mental State Examination( MMSE), National Institutes of Health Stroke Scale(NIHSS) and Activities of Daily Living(ADL)were given in to both groups. ResultsAfter 6 to 12 weeks' therapy, the total score of HAMD, NIHSS and ADL of Vinpoeetine group were significantly lower than the control group ( all P ＜ 0.05 ), MMSE score increased significantly ( P ＜ 0.05 ) in Vinpocetine group. The curative rate and effective rate of Vinpocetine group were 38％ and 91％. It was significantly higher than the 20％ and 73％ of the control group ( all P ＜ 0.05 ). ConclusionVinpocetine sustainedrelease capsules was effective to treat post-stroke depression. It could improve the emotional state of patients and promote the recovery of neurological function.
