The curative effects of jet nebulization with sodium bicarbonate on the patients withbronchial asthma
10.3760/cma.j.issn.1008-6706.2011.17.019
- VernacularTitle:碳酸氢钠雾化吸入治疗支气管哮喘的疗效观察
- Author:
Huiling CHEN
- Publication Type:Journal Article
- Keywords:
Sodium bicarbonate;
Nebulization;
Bronchial asthma
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(17):2341-2342
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of jet nebulization with sodium bicarbonate on the children with bronchial asthma.Methods 128 children with bronchial asthma were collected and randomly divided into observation group and control group. Conventional treatment by anti-infection and jet nebulization with hormone and bronchodilators were used in control group. Jet nebulization with sodium bicarbonate combination with conventional treatment was used in observation group. The therapeutic efficacy, clinical symptom, physical sign, the stay time, the occurrence of adverse reaction and the levels of IL-6, IL-8 and TNF-α in peripheral blood were observed. Results There were no severity adverse reactions happened in the two groups. The excellence rate was 59.4％ and total effective rate was 95. 3％ in observation group which were significantly higher that in control group( P ＜ 0. 05 ). The extinction time of clinical symptom and physical sign were significantly shorter than that in control group. The levels of IL-6, IL-8 and TNF-α in peripheral blood decreased notably after therapy than before treatment in the two groups. The decreased changes in observation group were significant than that in control group ( P ＜ 0. 05 ). Conclusion Jet nebulization with sodium bicarbonate could improve the clinical symptom and physical sign and shorten the course of disease of children with bronchial asthma. It also could decrease the secrete of inflammatory factor and get satisfactory curative effect.
