The observation of clinical effectiveness of adefovir combined with Anfate in treatment of patients with decompensated cirrhosis
10.3760/cma.j.issn.1008-6706.2011.17.026
- VernacularTitle:阿德福韦酯联合复方牛胎肝提取物治疗失代偿期肝硬化疗效观察
- Author:
Yongsheng YU
;
Lili WANG
;
Yanping LIU
;
Chunyan ZHANG
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Hepatitis B chronic;
Liver extracts;
Adefovir
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(17):2354-2356
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects and safety of adefovir combined with anfate(compound fetal cow liver extract tablets)in treament of patients with decompensated cirrhosis caused by chronic hepatitis B.Methods 45 decompensated cirrhosis patients with HBsAg, HBeAb-Positive HBcAb-Positive( 103Copies/ml ＜ HBV-DNA Level ＜10^6 Copies/ml)were randomly divided into conventional therapy group and with adefovie Combined Anfate Aapsule treatment. The clinical effectiveness after 6months was observed. Results The rates of serum ALT normalization,HBV-DNA levels undetectable( ＜ 103copies/ml) ,were 75.0％ (18/24) ,45.8％ (11/24). in adefovie combined Anfate treatment group and 76.1％ ( 16/21 ) ,42.8 ％ (9/21 )in control group, there was no statistically significant difference between the two groups after 6months( P ＞ 0.05 ). Hepatic fibrosis index as HA, LN,PC3 were decreased in two groups. There was respectively between the two groups, ,in the therapy group the rate patients got distinct improvement about the clinical symptoms was 87.5％ ( 21/24 ), which was remarkably higher than placebo group's 52.4％( 11/21 ). ( P ＜ 0.05). There was no ebidence of renal toxicity. Conclusion The effect of adefovir combined with anfate in treatment of decompensated cirhosis was stable and safe for.
