The relationship between the expression of hypoxia-induciable factor-1α and changes of hepatitis microcirculation in patients with chronic hepatitis B

VernacularTitle:慢性乙型肝炎患者肝组织低氧诱导因子-1α表达与肝脏微循环改变的关系
Author: Tilong DING ; Yong MA ; Lie SHENL ; Wenxue ZHANG
Publication Type:Journal Article
Keywords: Hepatitis B,chronic; Hypoxia-induciable factor; Microcirculation disturbance
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(17):2317-2318
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between the expression of Hypoxia-induciable factor-1α (HIF-1α) and changes of hepatitis microcimulation in patients with chronic hepatitis B (CHB).Methods 120 patients with CHB were studied. The expression of HIF-1 α was observed by immunohistochemistry and the morphotogic changes were observed with transmission eletron microscope. Results Stenosis, blockage, dilataltion, capillarization of hepatic sinusoids were the main morphotogic changes of liver. The expression of HIF-1α was positive or stronger positive. There is a positive correlation between the expression of HIF-1α and microcirculation disturbance of liver.Conclusion The disturbance of liver with CHB could exacerbate the dysbolism of nutrient substance and oxygen between hepatic cells and blood circulation. Hypoxia of hepatic cells was an important reason of the liver's pathological changes.