Experimental study on the effect of Ginsenoside Rg1 on the pathological changes of rat optic nerve injury
10.3760/cma.j.issn.1008-6706.2011.18.003
- VernacularTitle:人参皂苷Rg1对大鼠视神经损伤病理改变的实验研究
- Author:
Bo HUANG
;
Fangwei YING
;
Qiaoyan LONG
;
Wenxue HU
- Publication Type:Journal Article
- Keywords:
Ginsenoside Rg1;
Optic nerve injury;
Neuroprotective drugs
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(18):2453-2454
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect of ginsenoside Rg1 on the pathological changes of rat optic nerve injury. MethodsThe model of rat optic nerve injury was established, the rats were divided into the experimental group and control group,intraperitonealiy injected ginsenosides Rgl (10mg/kg) to experimental group of rats for 20days ,meanwhile intraperitonealiy injected the same volume of saline to the control group,took eyeball and optic nerve from the optic nerve injury eye and the normal eye in both groups ,HE staining,SABC immunohistochemical staining of Bcl-2, neurocan were analyzed. ResultsHE staining results showed the morphological difference on optic nerve cells from control group and the optic nerve injury group. Immunohistochemistry showed the neuronal cell apoptosis was significantly increased after optic nerve injury. The intraperitoneal injection of ginsenoside Rg1 could significantly improve the situation of cell apoptosis. The significant increment of fiber protein may be partly related to the improvement of cell apoptosis, but the principle was not clear. ConclusionGinsenoside Rg1 had protective effect on rat optic nerve injury.
