Controlled observation of ieflunomide and cyclophosphamide on lupus nephritis

VernacularTitle:来氟米特与环磷酰胺治疗狼疮肾炎的对照观察
Author: Xiaoling YUAN ; Zhaojun GUO ; Jiachang LIU ; Fanglin LU ; Haigeng CHEN
Publication Type:Journal Article
Keywords: Leflunomide; Cyclophosphamide; Lupus nephritis
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(18):2481-2482
CountryChina
Language:Chinese
Abstract: ObjectiveTo compare the therapeutic effect, adverse effects and safety of leflunomide (LEF)and cyclophosphamide(CTX) on lupus nephritis(LN). Methods43 patients with reactive LN were randomly divided into two groups. Based on hormone application,22 cases in LEF group were given LEF orally and 21 cases in CTX group were given CTX intravenous drip discontinuously. They were followed up for six months. The related indexes and possible concomitant adverse effects were detected. ResultsThe total effective rate in LEF group was 81.8％ and that in CTX group was 85.7％. The tolerance in LEF group was better and 3 cases had adverse effects. 13 cases in CTX group had adverse effects. ConclusionLEF had the same efficacy as CTX in the LN therapy, but the tolerance is better and the side effects are minor than CTX.