Expression of E-cadherin and β-catenin in primary colorectal carcinoma and metastatic lymph nodes and it's clinical significance
10.3760/cma.j.issn.1008-6706.2011.15.003
- VernacularTitle:上皮型钙黏附蛋白、β-连接素在结直肠癌及转移灶组织中的表达及临床意义
- Author:
Jianzhi CHEN
;
Xuan LI
;
Qi YAO
;
Xiuhuai CAO
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
E-cadherin;
β-catenin;
Neoplasms metastasis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(15):2022-2024
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the expression of E-cadherin and β-catenin in the primary colorectal carcinoma and metastatic lymph nodes and it's clinical significance. MethodsImmunohistochemical analysis of Ecadherin and β-catenin was performed in colorectal mucosa( n =20 ,group A) ,colorectal carcinoma without metastasis ( n = 25, group B) and colorectal carcinoma with metastatic lymph nodes ( n = 39, group C) The expression of E-cadherin and β-catenin and the metastasis and prognosis of colorectal carcinoma were observed. ResultsThe strongly positive expression of E-cadherin in primaries of group C (5.1％ ) was obviously lower than in group B ( U = 2. 149,P =0. 032) ,whereas no statistic differences of the expression of E-cadherin between primaries and metastases of group C were observed(P =0.186). There was no difference of the expression of β-catenin between group B and group C,the same of primary colorectal carcinoma and self control lymph nodes of group C(P =0.235 and P =0. 715). There was positive correlation between membranous down regulation of E-cadherin and β-catenin in group C( r = 0.387 ,P =0.024) ,but no relationship was found in group B( r = 0.080 ,P = 0.723 ). ConclusionThe decreased membranous expression of E-cadherin in the colorectal carcinoma was correlated with lymph nodes metastasis, and was obviously related to membranous down regulation of β-catenin. There was no relevance between the expression of β-catenin and the lymph nodes metastasis of colorectal carcinoma.
