The effects of clopidogrel on inflammatory cytokines in patients with coronary heart disease(CHD) after percutaneous coronary intervention(PCI)

VernacularTitle:冠心病患者介入治疗后氯吡格雷不同疗程对血清白介素-18和C-反应蛋白的影响
Author: Zonghu WU ; Shujuan WANG
Publication Type:Journal Article
Keywords: Radioactirity,Interventional; Clopidogrel
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(15):2048-2049
CountryChina
Language:Chinese
Abstract: ObjectiveTo observe the effects of clopidogrel on inflammatory cytokines in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). Methods68 cases diagnosed of CHD were randomly divided into clopidogrel 1 month group( group A), clopidogrel 6 months (roup B), every group had 34 cases. Before and after treatment adopt fasting blood respectively and in determination of serum interleukin-18 (IL-18)and C-reactive protein(hs-CRP). ResultsIL-18 and CRP were reduced more apparently in group B. Compared with group A,there were significant differences (P ＜ 0.05 ). ConclusionClopidogrel could significandy reduce coronary heart disease patients in which based on conventional treatment postoperative PCI inflammatory reaction, reduce the patients with coronary artery disease postoperative PCI vascular inflammatory reaction.