A clinical controlled study on schizophrenia treated with paliperidone-ER and risperidone

VernacularTitle:帕潘立酮与利培酮用于精神分裂症的对比分析
Author: Changhai GONG
Publication Type:Journal Article
Keywords: Paliperidone; Risperdal; Schizophrenia
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(17):2339-2340
CountryChina
Language:Chinese
Abstract: Objective To compare the efficacy and side effects of paliperidone-ER and risperidone in treating schizophrenia.Methods 60 patients of schizophrenia were treated with paliperidone-ER( n = 30) or risperidone (n =30) randomly,for 8 weeks. The efficacy was assessed with the positive and negative symptoms scale( PANSS), and the safety was assessed with treatment emergent symptoms scale before treatment and at the ends of week 1,2,4and 8 treatments,respectively. Results The PANSS scores of two groups were significantly decreased after the patients received the drug treatment. Paliperidone-ER group showed lower negative symptom score at week 4 and 8 than risperidone group. The efficacy of study group was significantly higher than that of control group. Conclusion Paliperidone-ER was effective and safe antipsychotic drug with significant improvement compared with risperidone in negative symptoms.