The role of soluble intercelluar adhesion molecule-1 in the pathogenesis of bronchial asthma

VernacularTitle:可溶性细胞间黏附分子-1与支气管哮喘病情程度的关系
Author: Weidong PENG ; Huaying WANG ; Zhongming FU ; Wanjun YU ; Gengyun SUN
Publication Type:Journal Article
Keywords: Bronchial asthma; Cell adhesion molecules
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(17):2358-2359
CountryChina
Language:Chinese
Abstract: Objective To study the role of soluble intercellular adhesion molecule-1 ( sICAM-1 ) in the pathogenesis of adults bronchial asthma and analyze the relationship between the level of sICAM-1 and the severity of bronchial asthma.Methods Serum levels of sICAM-1 in 134 cases with different periods of bronchial asthma patients and healthy volunteers were measured by ELISA and pulmonary functions of acute asthma patients were determined by pulmonary function analyzer. Results Serum sICAM-1 levels in 63 cases of acute asthma patients were increased significantly when compared with those in remission asthma patients and healthy volunteers and its value was increased significantly with the exacerbation of asthma;A negatively correlation between FEV1％ of pulmonary function and serum sICAM-1 level in patients with acute asthma was found in this study. Conclusion sICAM-1 was one of the important adhesion molecules in the pathogenesis of bronchial asthma. It could be used as one indicator of disease severity and guide the drug application in clinic.