Influence of cytarabine on proliferation and Apoptosis of K562 cells
10.3760/cma.j.issn.1008-6706.2011.15.021
- VernacularTitle:阿糖胞苷对白血病K562细胞增殖和凋亡的影响
- Author:
Li RONG
- Publication Type:Journal Article
- Keywords:
Cytarabine;
Leukemia;
Drug Therapy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(15):2056-2057
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the mechanisms of proliferation and apoptosis of K562 cells induced by cytarabine. MethodsDifferent doses of cytarabine on the proliferotion at K562 cell 24h,48h,72h were detected by MTT. Cell cycle And Apoptosis rate were detected by FCM. ResultsEach concentration of cytarabine obvious inhibited the growth of K562 cells. In the same concentrations,function of proliferation inhibition with cytarabine increased by the extension of time,which showed dose and time effect relations. Cytarabine on K562 cell,G0/G1 phase cell proportion of role as cytarabine increased when extension of time, S period and the G2/M period cells were decreased.Apoptosis of K562 cell in proportion as drug concentration and effect time increases, which present Cytarabine timeconcentration dependence. CondusionCytarabine was apparent inhibition to proliferation of K562 cell leukemia cell, which could promote K562 cell apoptosis by time and concentration dependence way.
