The protective effects of Qiqiong Capsule on focal cerebral ischemia/reperfusion injury

VernacularTitle:芪穹胶囊对大鼠局部脑缺血再灌注损伤的保护作用
Author: Yuguo REN ; Xia LI ; Huan HUANG ; Yanyan YIN ; Weizu LI
Publication Type:Journal Article
Keywords: Cerebral ischemia/reperfusion injury; Free radical; Thrombogenesis; Platelet aggregation
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(16):2184-2186
CountryChina
Language:Chinese
Abstract: ObjectiveTo study the protective effects of Qiqiong(QQJN) on focal cerebral ischemia/reperfusion injury and its mechanism. MethodsMiddle cerebral artery occlusion(MCAO) was used to make focal cerebral ischemia/reperfusion model by intravascular nylon filament occlusion. The protective effects of QQJN were evaluated by investigating neurological function score, percentage of cerebral infarction, pathomorphology of brain, the activity of SOD and the content of MDA in hrain tissue,thrombogenesis and platelet aggregation in vitro. ResultsCompared with model group, QQJN(4.4、8.8g/kg)could decrease the neurological score in 8 and 22h after reperfusion, reduce the percentage of cerebral infauction,improve pathomorphology of brain, decrease the length, wet weight and dry weight of thromb and inhibit platelet aggregation. ConclusionQQJN had protective effects on focal cerebral ischemia/reperfusion injury. The role of anti-injury of free radicals,inhibit thrombogenesis and platelet aggregation should contribute to its neuroprotective effects.