Gene therapy for pancreatic cancer
10.3760/cma.j.issn.1673-4203.2011.09.016
- VernacularTitle:胰腺癌基因治疗的研究现状
- Author:
Hao LIU
;
Yantao TIAN
- Publication Type:Journal Article
- Keywords:
Pancreatic cancer;
Gene therapy;
Recent advances
- From:
International Journal of Surgery
2011;38(9):625-628
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer was one of common malignant tumors of the digestive tract, early diagnosis of which was difficult and surgical resection rate was low. The prognosis was poor, and its incidence increased year by year. Conventional treatment of pancreatic cancer includes surgery, radiotherapy and chemotherapy, but 90％ of the patients had lost the surgical opportunity when they see a doctor, and not sensitive to radiotherapy and chemotherapy. Relative to these traditional treatments, gene therapy is an innovative approach for the treatment of pancreatic cancer and had attracted wide attention in recent years. Many gene therapy drugs for pancreatic cancer had now entered Ⅰ / Ⅱ clinical trials. The gene therapy techniques for pancreatic cancer included antisense gene therapy, suicide gene therapy, immune gene therapy, and oncolytic virus therapy. In this article, we reviewed recent advances in gene therapy for pancreatic cancer.
