Comparative study on quantitative parameters of blood perfusion and microvessel density in placenta of rat model of preeclampsia evaluted with contrast-enhanced ultrasound
10.3760/cma.j.issn.1004-4477.2011.09.028
- VernacularTitle:妊娠高血压综合征模型母鼠胎盘超声造影测量血流灌注与病理微血管密度对比分析
- Author:
Yangqing XU
;
Xinlin CHEN
;
Xiaohong YANG
;
Xiaojun LU
;
Peiwen CHEN
;
Junhong HUANG
;
Lei HU
;
Cheng HUANG
;
Zhaoling LU
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Hypertension,pregnancy-induced;
Placenta;
Hemodynamic phenomena
- From:
Chinese Journal of Ultrasonography
2011;20(9):808-810
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between quantitative parameters with contrastenhanced ultrasound (CEUS) and microvessel density (MVD).Methods Thirty-four placenta of rat model of preeclampsia underwent CEUS examination.The peak intensity time curves on the enhanced images were analyzed quantitatively with computer to get quantitative parameters[the time to peak(TTP), maximal peak intensity(Imax), the area under curve(AUC) and the mean perfusion volume(V)].These parameters were compared with MVD counted with immunohistochemistry and the correlation was statistically studied.Results The TTP in the enhanced images was (14.55 ± 3.45)s, Imax was (20.83 ± 6.15) dB, AUC was (1868.61 ± 25.76)dB, V was (58.01 ± 23.56)dB, and the MVD of placenta of rat model of preeclampsia was (88.98 ± 24.78) in 34 rats.The Imax was correlated positively to MVD (r = 0.885, P = 0.000) ,AUC was correlated positively to MVD (r = 0.677, P = 0.001), V was correlated positively to MVD (r =0.877, P = 0.000).There was no correlation between TTP and MVD in lesions.Conclusions The Imax,AUC and V calculated with CEUS were correlated to MVD, these parameters were valuable index for quantitative evaluation of placental blood perfusion.
