Autologous peripheral blood stem cells transplantation for the treatment of diabetic vascular disorder in lower extremities
10.3760/cma.j.issn.1008-6315.2011.09.023
- VernacularTitle:自体外周血干细胞移植治疗糖尿病下肢缺血效果观察
- Author:
Hua LI
;
Xuyan CHEN
;
Lianghua FENG
;
Zhigao DONG
;
Pingping XIAO
;
Wanting WU
;
Wenfeng HUANG
- Publication Type:Journal Article
- Keywords:
Autologous peripheral blood stem cells transplantation;
Diabetic lower limb ischemia;
Ankle-brachial index;
Transcutaneous (partial) pressure of oxygen
- From:
Clinical Medicine of China
2011;27(9):958-961
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the efficiency of autologous transplantation of peripheral blood stem cells for treatment of patients with diabetic lower limb ischemia.MethodsEighteen patients of type 2 diabetes with diabetic lower limb ischemia (30 legs) were treated by autologous transplantation of peripheral blood stem cells.ResultsThe limb pain, cool feeling and numbness feeling improved significantly after PBSC transplantation,the improvement rate were 96.7％, 100.0％ and 95.8％ respectively.Intermittent claudication was also relieved significantly, total remission rate was 76.9％.The ABI and TcPO2 of patients increased significantly at 3 months after transplantation.After the transplantation ABI raised from 0.60 ± 0.11 to 0.71 ±0.12(t =-6.882, P ＜ 0.01) .93.3％ of patients' TcPO2 raised in different degrees.The foot infections were well controlled.Ulcer or toes gangrene got better or healed.No obvious complications or adverse reaction were observed after the transplantation.ConclusionAutologous transplantation of peripheral blood stem cells shows to be a simple, safe and effective method in treating patients with diabetic lower limb ischemia.
