N-acetylcysteine protects against liver injury in rats with obstructive jaundice

VernacularTitle:N-乙酰半胱氨酸对大鼠胆道梗阻肝功能损伤的保护作用及机制研究
Author: Yong TANG ; Jianfeng HE ; Caijun FANG ; Jing ZHANG ; Jing ZHANG ; Jianping GONG
Publication Type:Journal Article
Keywords: N-acetylcysteine; Obstructive jaundice; Liver injury
From: Chinese Journal of Hepatobiliary Surgery 2011;17(9):768-770
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the mechanisms of N-acetylcysteine protection against liver injury caused by biliary tract obstruction in rats. MethodsSeventy-two Wistar rats were divided randomly into the following three groups: (1) Rats received choledochus ligationon and N-acetylcysteine by intraperitoneal injection (DBL+NAC); (2) Rats received choledochus ligationon only; (3) sham operation. Six rats were killed each time after 1 d, 3 d, 5 d and7 d and their liver function was tested by TBA-40FR Automatic Chemistry Analyzer. In addition, NO production was detected by Griess Reagent System. ResultsWhen the period of biliary duct obstruction is extended, serum AST,ALT,TBIL, DBIL, NO and TNF-α increase but the increase in serum ALT,AST,NO and TNF-α(P＜0. 05) is more prominent in group DBL than group DBL+NAC at any given time. Conclusions N-acetylcysteine can effectively protect against liver injury in rats with obstructive jaundice, and this may be achieved through down-regulation of TNF-α and NO in hepatocytes.