Analysis on blood glucose excursion in men with nonalcoholic fatty liver disease

VernacularTitle:男性非酒精性脂肪性肝病患者血糖波动研究
Author: Chunmei QIN ; Qiang LU ; Ji FENG ; Fuzai YIN ; Rui WANG ; Bo LIU ; Chunming MA ; Juntao SHAO
Publication Type:Journal Article
Keywords: Nonalcoholic fatty liver disease; Blood glucose excursion; Male
From: Chinese Journal of Endocrinology and Metabolism 2011;27(9):736-738
CountryChina
Language:Chinese
Abstract: Forty-eight men with normal glucose tolerance were divided into fatty liver disease ( NAFLD, n =23 ) and non-NAFLD (n =25 ) groups. The blood glucose excursion was evaluated by continuous glucose monitoring system. The results showed that the mean amplitude of glucose excursion[MAGE, (2. 17± 1.13 vs 1.45±0. 42 )mmol/L]and standard deviation of blood glucose[SDBG, (0. 88 ±0. 45 vs 0. 61 ±0. 21 ) mmol/L]were significantly higher in NAFLD group than in non-NAFLD group( both P＜0. 05 ). MAGE and SDBG were positively correlated with body mass index, waist circumference, and the increased value of plasma glucose 0. 5 h after glucose loading( △G30,all P＜0. 05 ). In multiple regression analysis, △G30, waist circumference, and age were significant independent predictors for MAGE( P＜0. 05 or P＜0. 01 ). △G30 and waist circumference were significant independent predictors for SDBG( P＜0. 05 or P＜0. 01 ).