The update of the relationship between nonalcoholic fatty liver disease and atherosclerosis

VernacularTitle:非酒精性脂肪性肝病与动脉粥样硬化之间关系的研究进展
Author: Xiaoming LI ; Xin GAO
Publication Type:Journal Article
Keywords: Nonalcoholic fatty liver disease; Atherosclerosis; Cardiovascular disease; Insulin resistance; Carotid intima-media thickness
From: Chinese Journal of Endocrinology and Metabolism 2011;27(9):784-786
CountryChina
Language:Chinese
Abstract: Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, type 2 diabetes,dyslipidemia, hypertension, and metabolic syndrome.It likely represents hepatic manifestation of metabolic syndrome. The prevalence of NAFLD has been estimated to be 20％-30％ in the general population. However, it is much higher in type 2 diabetic patients. Several epidemiological studies indicate that NAFLD is linked to an increased risk of cardiovascular disease( CVD), which is independent of underlying cardiometabolic risk factors. This suggests that NAFLD may also be actively involved in the pathogenesis. The possible molecular mediators linking NAFLD and atherosclerosis(AS) include the release of pro-atherogenic factors by oxidative stress and inflammation as well as atherogenic dyslipidemia, abnormal adipose factors, and insulin resistance, finally aggravating progression of CVD. In this article, the relationship and possible mechanisms between NAFLD and AS are reviewed.